USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P0CG48 USC-OGP 2-DE database:  P0CG48 P0CG48 General information about the entry View entry in simple text format Entry name UBC_HUMAN Primary accession number P0CG48 Secondary accession number(s) P62988 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Polyubiquitin-C; Contains: RecName: Full=Ubiquitin; Flags: Precursor;. Gene name Name=UBC Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1299: pI=4.88; Mw=23684 SPOT OGP-1361: pI=6.95; Mw=11105 Cross-references UniProtKB/Swiss-Prot P0CG48; UBC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UBC_HUMAN Primary accession number P0CG48 Secondary accession number(s) P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7 Sequence was last modified on  June 13, 2012 (version 3) Annotations were last modified on  March 15, 2017 (version 76) Name and origin of the protein Description RecName: Full=Polyubiquitin-C; Contains: RecName: Full=Ubiquitin; Flags: Precursor; Gene name Name=UBC Encoded on Name=UBC Keywords 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M26880; AAA36789.1; -; mRNA EMBL AB009010; BAA23632.1; -; mRNA EMBL AB089613; BAC56951.1; -; Genomic_DNA EMBL AC126309; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC039193; AAH39193.1; -; mRNA EMBL D63791; BAA09860.1; -; Genomic_DNA EMBL AB003730; BAA23486.1; -; Genomic_DNA EMBL M17597; AAA36787.1; -; mRNA CCDS CCDS9260.1; -; . PIR A02574; UQHU; . PIR A22005; UQHUC; . PIR A29526; A29526; . RefSeq NP_066289.3; NM_021009.6; . UniGene Hs.520348; -; . UniGene Hs.707528; -; . UniGene Hs.731841; -; . PDB 1C3T; NMR; -; A=1-76 PDB 1CMX; X-ray; 2.25 A; B/D=1-76 PDB 1D3Z; NMR; -; A=1-76 PDB 1F9J; X-ray; 2.70 A; A/B=1-76 PDB 1FXT; NMR; -; B=1-76 PDB 1G6J; NMR; -; A=1-76 PDB 1GJZ; NMR; -; A/B=1-51 PDB 1NBF; X-ray; 2.30 A; C/D=1-76 PDB 1OGW; X-ray; 1.32 A; A=1-76 PDB 1Q5W; NMR; -; B=1-76 PDB 1S1Q; X-ray; 2.00 A; B/D=1-76 PDB 1SIF; X-ray; 2.18 A; A=6-76 PDB 1TBE; X-ray; 2.40 A; A/B=1-76 PDB 1UBI; X-ray; 1.80 A; A=1-76 PDB 1UBQ; X-ray; 1.80 A; A=1-76 PDB 1UD7; NMR; -; A=1-76 PDB 1XD3; X-ray; 1.45 A; B/D=1-75 PDB 1XQQ; NMR; -; A=1-76 PDB 1YX5; NMR; -; B=1-76 PDB 1YX6; NMR; -; B=1-76 PDB 1ZGU; NMR; -; B=1-76 PDB 1ZO6; Model; -; B/C=1-76 PDB 2AYO; X-ray; 3.50 A; B=1-76 PDB 2BGF; NMR; -; A/B=1-76 PDB 2DEN; NMR; -; B=1-76 PDB 2FUH; NMR; -; B=1-76 PDB 2G45; X-ray; 1.99 A; B/E=1-76 PDB 2GBJ; X-ray; 1.35 A; A/B=1-76 PDB 2GBK; X-ray; 1.99 A; A/B/C/D=10-76 PDB 2GBM; X-ray; 1.55 A; A/B/C/D=1-76 PDB 2GBN; X-ray; 1.60 A; A=1-76 PDB 2GBR; X-ray; 2.00 A; A/B/C=1-76 PDB 2GMI; X-ray; 2.50 A; C=1-76 PDB 2HTH; X-ray; 2.70 A; A=1-76 PDB 2IBI; X-ray; 2.20 A; B=1-75 PDB 2J7Q; X-ray; 1.80 A; B/D=1-75 PDB 2JF5; X-ray; 1.95 A; A/B=1-76 PDB 2JRI; NMR; -; B/C=1-76 PDB 2JY6; NMR; -; A=1-76 PDB 2JZZ; NMR; -; A=1-76 PDB 2K25; NMR; -; A=1-75 PDB 2K6D; NMR; -; B=1-75 PDB 2K8B; NMR; -; A=1-76 PDB 2K8C; NMR; -; A=1-76 PDB 2KDF; NMR; -; B/C=1-76 PDB 2KHW; NMR; -; B=1-76 PDB 2KJH; NMR; -; B=1-75 PDB 2KLG; NMR; -; A=1-76 PDB 2KN5; NMR; -; A=1-76 PDB 2KX0; NMR; -; A=74-151 PDB 2L3Z; NMR; -; A=1-76 PDB 2LD9; NMR; -; A=76-152 PDB 2LVO; NMR; -; A=1-76 PDB 2LVP; NMR; -; A/B=1-76 PDB 2LVQ; NMR; -; A/B=1-76 PDB 2LZ6; NMR; -; A=609-684 PDB 2MBO; NMR; -; A/B=609-684 PDB 2MBQ; NMR; -; A/B=609-684 PDB 2MCN; NMR; -; B=609-684 PDB 2MI8; NMR; -; A=609-684 PDB 2MJ5; NMR; -; A=609-684 PDB 2MOR; NMR; -; A=609-684 PDB 2MRE; NMR; -; A=609-684 PDB 2MWS; NMR; -; A=609-684 PDB 2N2K; NMR; -; A=609-684 B=609-679 PDB; 2NR2; NMR; - A=1-76 PDB; 2O6V; X-ray; 2.20 A A/B/C/D/E/F/G/H=1-76 PDB; 2OJR; X-ray; 2.60 A A=1-76 PDB; 2PE9; NMR; - A/B=1-76 PDB; 2PEA; NMR; - A/B=1-76 PDB; 2RR9; NMR; - A/B=1-76 PDB; 2RU6; NMR; - A=609-684 PDB; 2W9N; X-ray; 2.25 A A=1-152 PDB; 2WDT; X-ray; 2.30 A B/D=1-75 PDB; 2XEW; X-ray; 2.20 A A/B/C/D/E/F/G/H/I/J/K/L=1-76 PDB; 2Y5B; X-ray; 2.70 A B/F=1-152 PDB; 2Z59; NMR; - B=1-76 PDB; 2ZCB; X-ray; 1.60 A A/B/C=1-76 PDB; 2ZVN; X-ray; 3.00 A A/C/E/G=1-152 PDB; 2ZVO; X-ray; 2.90 A A/G=1-152 PDB; 3A33; X-ray; 2.20 A B=1-76 PDB; 3ALB; X-ray; 1.85 A A/B/C/D=1-76 PDB; 3AUL; X-ray; 2.39 A A/B=1-76 PDB; 3B08; X-ray; 1.70 A A/D/G/J=1-152 PDB; 3B0A; X-ray; 1.90 A A/D=1-152 PDB; 3BY4; X-ray; 1.55 A B=1-75 PDB; 3C0R; X-ray; 2.31 A B/D=1-75 PDB; 3DVG; X-ray; 2.60 A X/Y=1-76 PDB; 3DVN; X-ray; 2.70 A U/V/X/Y=1-76 PDB; 3EEC; X-ray; 3.00 A A/B=1-76 PDB; 3EFU; X-ray; 1.84 A A=1-76 PDB; 3EHV; X-ray; 1.81 A A/B/C=1-76 PDB; 3H7P; X-ray; 1.90 A A/B=1-76 PDB; 3H7S; X-ray; 2.30 A A/B=1-76 PDB; 3HM3; X-ray; 1.96 A A/B/C/D=1-76 PDB; 3I3T; X-ray; 2.59 A B/D/F/H=1-75 PDB; 3IFW; X-ray; 2.40 A B=1-75 PDB; 3IHP; X-ray; 2.80 A C/D=1-75 PDB; 3JSV; X-ray; 2.70 A A/B=1-76 PDB; 3JVZ; X-ray; 3.30 A X/Y=1-76 PDB; 3JW0; X-ray; 3.10 A X/Y=1-76 PDB; 3K9O; X-ray; 1.80 A B=76-151 PDB; 3K9P; X-ray; 2.80 A B=1-76 PDB; 3KVF; X-ray; 2.80 A B=1-75 PDB; 3KW5; X-ray; 2.83 A B=1-75 PDB; 3LDZ; X-ray; 2.60 A E/F/G=1-73 PDB; 3MHS; X-ray; 1.89 A D=1-76 PDB; 3MTN; X-ray; 2.70 A B/D=1-76 PDB; 3N30; X-ray; 3.00 A A/B=1-76 PDB; 3N32; X-ray; 1.80 A A=1-76 PDB; 3N3K; X-ray; 2.60 A B=5-76 PDB; 3NS8; X-ray; 1.71 A A/B=1-76 PDB; 3O65; X-ray; 2.70 A B/D/F/H=1-75 PDB; 3OFI; X-ray; 2.35 A C/D=1-76 PDB; 3OJ3; X-ray; 2.50 A A/B/C/D/E/F/G/H=1-76 PDB; 3OJ4; X-ray; 3.40 A B/E=1-76 PDB; 3ONS; X-ray; 1.80 A A=1-72 PDB; 3PRM; X-ray; 2.30 A B/D=1-75 PDB; 3PT2; X-ray; 2.50 A B=1-75 PDB; 3PTF; X-ray; 2.70 A C/D=1-76 PDB; 3Q3F; X-ray; 2.17 A A=2-76 PDB; 3RUL; X-ray; 2.50 A A/B/C/D=1-75 PDB; 3TMP; X-ray; 1.91 A B/D/F/H=1-76 PDB; 3U30; X-ray; 2.43 A A/D=1-152 PDB; 3UGB; X-ray; 2.35 A B=1-76 PDB; 3V6C; X-ray; 1.70 A B=74-150 PDB; 3V6E; X-ray; 2.10 A B=74-150 PDB; 3VFK; X-ray; 2.80 A A=1-75 PDB; 3VUW; X-ray; 1.95 A A/B/C=1-76 PDB; 3VUX; X-ray; 1.70 A A/B/C=1-76 PDB; 3VUY; X-ray; 1.98 A A/B/C=1-76 PDB; 3WXE; X-ray; 2.50 A B=533-680 PDB; 3WXF; X-ray; 2.30 A B/D=533-680 PDB; 3ZLZ; X-ray; 2.90 A A/B=1-76 PDB; 3ZNH; X-ray; 2.30 A B=1-75 PDB; 3ZNI; X-ray; 2.21 A D/H/L/P=1-76 PDB; 3ZNZ; X-ray; 1.90 A B=1-152 PDB; 4AP4; X-ray; 2.21 A C/F=608-684 PDB; 4AUQ; X-ray; 2.18 A C/F=1-76 PDB; 4BOS; X-ray; 2.35 A C/E=609-684 F=612-625; PDB; 4BOZ; X-ray 3.03 A B/C/E=1-76; PDB; 4BVU; X-ray 2.70 A C=609-684; PDB; 4DDG; X-ray 3.30 A D/E/F/G/H/I/M/N/O/P/Q/R=1-76; PDB; 4DDI; X-ray 3.80 A G/H/I/J/K/L=1-76; PDB; 4DHJ; X-ray 2.35 A B/F/J/M=1-76; D/H=1-75; PDB; 4DHZ X-ray 3.11 A; B=1-76; E=1-75; PDB 4FJV X-ray; 2.05 A; B/D=1-76; PDB 4HK2 X-ray; 1.40 A; A/B/C/D=1-76; PDB 4HXD X-ray; 2.85 A; A/C=1-75; PDB 4I6L X-ray; 2.49 A; B=77-150; PDB 4I6N X-ray; 1.70 A; B/D=1-75; PDB 4IG7 X-ray; 2.00 A; B=1-75; PDB 4IUM X-ray; 1.45 A; B=1-75; PDB 4JQW X-ray; 2.90 A; C=609-684; PDB 4K1R X-ray; 1.63 A; B/D=607-684; PDB 4K7S X-ray; 1.76 A; A/B/C=1-76; PDB 4K7U X-ray; 1.76 A; A/B/C=1-76; PDB 4K7W X-ray; 1.76 A; A/B/C=1-76; PDB 4KSK X-ray; 2.40 A; C/D=76-152; PDB 4KSL X-ray; 2.83 A; C/D/F/H/J/L/N/P/R/T/V/X=76-228; PDB 4LCD X-ray; 3.10 A; E/F=609-683; PDB 4LDT X-ray; 1.90 A; B/D=609-684; PDB 4MDK X-ray; 2.61 A; E/F/G/H=608-684; PDB 4MM3 X-ray; 2.75 A; A=609-684; PDB 4MSM X-ray; 1.74 A; B/D=609-684; PDB 4MSQ X-ray; 1.95 A; B/D=609-684; PDB 4NQK X-ray; 3.70 A; E/F/G/H/I/J=608-684; PDB 4UN2 X-ray; 1.51 A; A=609-684; PDB 4V3K X-ray; 2.04 A; B/E=609-684; PDB 4V3L X-ray; 1.53 A; B/D=609-684; PDB 4WZP X-ray; 1.90 A; A/B/C/D/E/F/G/H=153-228; PDB 4XOK X-ray; 2.20 A; A/B/C=1-76; PDB 4XOL X-ray; 2.91 A; A/B=1-76; PDB 4ZQS X-ray; 1.80 A; A/B=533-684; PDB 5A5B EM; 9.50 A; 9=609-684; PDB 5AF4 X-ray; 1.85 A; A/B/C/D/E/F/G/H=1-76; PDB 5AF5 X-ray; 1.68 A; A=1-73; PDB 5AF6 X-ray; 3.40 A; A/B/C/D/E=1-76; PDB 5AIT X-ray; 3.40 A; C/F=609-684; PDB 5AIU X-ray; 2.21 A; C/F=609-684; PDB 5B83 X-ray; 2.69 A; A/D=1-304; PDB 5C7J X-ray; 3.00 A; C/D=1-74; PDB 5C7M X-ray; 3.03 A; B/C=1-75; PDB 5E6J X-ray; 2.85 A; B/E=609-683; PDBsum 1C3T -; . PDBsum 1CMX; -; . PDBsum 1D3Z; -; . PDBsum 1F9J; -; . PDBsum 1FXT; -; . PDBsum 1G6J; -; . PDBsum 1GJZ; -; . PDBsum 1NBF; -; . PDBsum 1OGW; -; . PDBsum 1Q5W; -; . PDBsum 1S1Q; -; . PDBsum 1SIF; -; . PDBsum 1TBE; -; . PDBsum 1UBI; -; . PDBsum 1UBQ; -; . PDBsum 1UD7; -; . PDBsum 1XD3; -; . PDBsum 1XQQ; -; . PDBsum 1YX5; -; . PDBsum 1YX6; -; . PDBsum 1ZGU; -; . PDBsum 1ZO6; -; . PDBsum 2AYO; -; . PDBsum 2BGF; -; . PDBsum 2DEN; -; . PDBsum 2FUH; -; . PDBsum 2G45; -; . PDBsum 2GBJ; -; . PDBsum 2GBK; -; . PDBsum 2GBM; -; . PDBsum 2GBN; -; . PDBsum 2GBR; -; . PDBsum 2GMI; -; . PDBsum 2HTH; -; . PDBsum 2IBI; -; . PDBsum 2J7Q; -; . PDBsum 2JF5; -; . PDBsum 2JRI; -; . PDBsum 2JY6; -; . PDBsum 2JZZ; -; . PDBsum 2K25; -; . PDBsum 2K6D; -; . PDBsum 2K8B; -; . PDBsum 2K8C; -; . PDBsum 2KDF; -; . PDBsum 2KHW; -; . PDBsum 2KJH; -; . PDBsum 2KLG; -; . PDBsum 2KN5; -; . PDBsum 2KX0; -; . PDBsum 2L3Z; -; . PDBsum 2LD9; -; . PDBsum 2LVO; -; . PDBsum 2LVP; -; . PDBsum 2LVQ; -; . PDBsum 2LZ6; -; . PDBsum 2MBO; -; . PDBsum 2MBQ; -; . PDBsum 2MCN; -; . PDBsum 2MI8; -; . PDBsum 2MJ5; -; . PDBsum 2MOR; -; . PDBsum 2MRE; -; . PDBsum 2MWS; -; . PDBsum 2N2K; -; . PDBsum 2NR2; -; . PDBsum 2O6V; -; . PDBsum 2OJR; -; . PDBsum 2PE9; -; . PDBsum 2PEA; -; . PDBsum 2RR9; -; . PDBsum 2RU6; -; . PDBsum 2W9N; -; . PDBsum 2WDT; -; . PDBsum 2XEW; -; . PDBsum 2Y5B; -; . PDBsum 2Z59; -; . PDBsum 2ZCB; -; . PDBsum 2ZVN; -; . PDBsum 2ZVO; -; . PDBsum 3A33; -; . PDBsum 3ALB; -; . PDBsum 3AUL; -; . PDBsum 3B08; -; . PDBsum 3B0A; -; . PDBsum 3BY4; -; . PDBsum 3C0R; -; . PDBsum 3DVG; -; . PDBsum 3DVN; -; . PDBsum 3EEC; -; . PDBsum 3EFU; -; . PDBsum 3EHV; -; . PDBsum 3H7P; -; . PDBsum 3H7S; -; . PDBsum 3HM3; -; . PDBsum 3I3T; -; . PDBsum 3IFW; -; . PDBsum 3IHP; -; . PDBsum 3JSV; -; . PDBsum 3JVZ; -; . PDBsum 3JW0; -; . PDBsum 3K9O; -; . PDBsum 3K9P; -; . PDBsum 3KVF; -; . PDBsum 3KW5; -; . PDBsum 3LDZ; -; . PDBsum 3MHS; -; . PDBsum 3MTN; -; . PDBsum 3N30; -; . PDBsum 3N32; -; . PDBsum 3N3K; -; . PDBsum 3NS8; -; . PDBsum 3O65; -; . PDBsum 3OFI; -; . PDBsum 3OJ3; -; . PDBsum 3OJ4; -; . PDBsum 3ONS; -; . PDBsum 3PRM; -; . PDBsum 3PT2; -; . PDBsum 3PTF; -; . PDBsum 3Q3F; -; . PDBsum 3RUL; -; . PDBsum 3TMP; -; . PDBsum 3U30; -; . PDBsum 3UGB; -; . PDBsum 3V6C; -; . PDBsum 3V6E; -; . PDBsum 3VFK; -; . PDBsum 3VUW; -; . PDBsum 3VUX; -; . PDBsum 3VUY; -; . PDBsum 3WXE; -; . PDBsum 3WXF; -; . PDBsum 3ZLZ; -; . PDBsum 3ZNH; -; . PDBsum 3ZNI; -; . PDBsum 3ZNZ; -; . PDBsum 4AP4; -; . PDBsum 4AUQ; -; . PDBsum 4BOS; -; . PDBsum 4BOZ; -; . PDBsum 4BVU; -; . PDBsum 4DDG; -; . PDBsum 4DDI; -; . PDBsum 4DHJ; -; . PDBsum 4DHZ; -; . PDBsum 4FJV; -; . PDBsum 4HK2; -; . PDBsum 4HXD; -; . PDBsum 4I6L; -; . PDBsum 4I6N; -; . PDBsum 4IG7; -; . PDBsum 4IUM; -; . PDBsum 4JQW; -; . PDBsum 4K1R; -; . PDBsum 4K7S; -; . PDBsum 4K7U; -; . PDBsum 4K7W; -; . PDBsum 4KSK; -; . PDBsum 4KSL; -; . PDBsum 4LCD; -; . PDBsum 4LDT; -; . PDBsum 4MDK; -; . PDBsum 4MM3; -; . PDBsum 4MSM; -; . PDBsum 4MSQ; -; . PDBsum 4NQK; -; . PDBsum 4UN2; -; . PDBsum 4V3K; -; . PDBsum 4V3L; -; . PDBsum 4WZP; -; . PDBsum 4XOK; -; . PDBsum 4XOL; -; . PDBsum 4ZQS; -; . PDBsum 5A5B; -; . PDBsum 5AF4; -; . PDBsum 5AF5; -; . PDBsum 5AF6; -; . PDBsum 5AIT; -; . PDBsum 5AIU; -; . PDBsum 5B83; -; . PDBsum 5C7J; -; . PDBsum 5C7M; -; . PDBsum 5E6J; -; . ProteinModelPortal P0CG48; -; . SMR P0CG48; -; . BioGrid 113164; 1440; . IntAct P0CG48; 172; . MINT MINT-97475; -; . STRING 9606.ENSP00000344818; -; . DrugBank DB04464; N-Formylmethionine; . iPTMnet P0CG48; -; . PhosphoSitePlus P0CG48; -; . SwissPalm P0CG48; -; . DMDM 391358178; -; . EPD P0CG48; -; . MaxQB P0CG48; -; . PaxDb P0CG48; -; . PeptideAtlas P0CG48; -; . PRIDE P0CG48; -; . TopDownProteomics P0CG48; -; . Ensembl ENST00000339647; ENSP00000344818; ENSG00000150991; . Ensembl ENST00000536769; ENSP00000441543; ENSG00000150991; . GeneID 7316; -; . KEGG hsa:7316; -; . UCSC uc001ugs.5; human; . CTD 7316; -; . DisGeNET 7316; -; . GeneCards UBC; -; . HGNC HGNC:12468; UBC; . HPA CAB000362; -; . HPA CAB005419; -; . HPA HPA041344; -; . HPA HPA049132; -; . MIM 191340; gene; . neXtProt NX_P0CG48; -; . OpenTargets ENSG00000150991; -; . eggNOG KOG0001; Eukaryota; . eggNOG COG5272; LUCA; . GeneTree ENSGT00810000125435; -; . InParanoid P0CG48; -; . KO K08770; -; . OMA TTINIKY; -; . OrthoDB EOG091G178I; -; . TreeFam TF354256; -; . Reactome R-HSA-110312; Translesion synthesis by REV1; . Reactome R-HSA-110314; Recognition of DNA damage by PCNA-containing replication complex; . Reactome R-HSA-110320; Translesion Synthesis by POLH; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1169408; ISG15 antiviral mechanism; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236382; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1253288; Downregulation of ERBB4 signaling; . Reactome R-HSA-1295596; Spry regulation of FGF signaling; . Reactome R-HSA-1358803; Downregulation of ERBB2:ERBB3 signaling; . Reactome R-HSA-162588; Budding and maturation of HIV virion; . Reactome R-HSA-168638; NOD1/2 Signaling Pathway; . Reactome R-HSA-168928; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways; . Reactome R-HSA-174048; APC/C:Cdc20 mediated degradation of Cyclin B; . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-174490; Membrane binding and targetting of GAG proteins; . Reactome R-HSA-175474; Assembly Of The HIV Virion; . Reactome R-HSA-179409; APC-Cdc20 mediated degradation of Nek2A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-182971; EGFR downregulation; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-201681; TCF dependent signaling in response to WNT; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-205043; NRIF signals cell death from the nucleus; . Reactome R-HSA-209543; p75NTR recruits signalling complexes; . Reactome R-HSA-209560; NF-kB is activated and signals survival; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2122947; NOTCH1 Intracellular Domain Regulates Transcription; . Reactome R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus; . Reactome R-HSA-2173788; Downregulation of TGF-beta receptor signaling; . Reactome R-HSA-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); . Reactome R-HSA-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity; . Reactome R-HSA-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2559580; Oxidative Stress Induced Senescence; . Reactome R-HSA-2559582; Senescence-Associated Secretory Phenotype (SASP); . Reactome R-HSA-2559585; Oncogene Induced Senescence; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-2644606; Constitutive Signaling by NOTCH1 PEST Domain Mutants; . Reactome R-HSA-2672351; Stimuli-sensing channels; . Reactome R-HSA-2691232; Constitutive Signaling by NOTCH1 HD Domain Mutants; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-2894862; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; . Reactome R-HSA-2979096; NOTCH2 Activation and Transmission of Signal to the Nucleus; . Reactome R-HSA-3134975; Regulation of innate immune responses to cytosolic DNA; . Reactome R-HSA-3322077; Glycogen synthesis; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-3769402; Deactivation of the beta-catenin transactivating complex; . Reactome R-HSA-3785653; Myoclonic epilepsy of Lafora; . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-400253; Circadian Clock; . Reactome R-HSA-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; . Reactome R-HSA-446652; Interleukin-1 signaling; . Reactome R-HSA-450302; activated TAK1 mediates p38 MAPK activation; . Reactome R-HSA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-4641263; Regulation of FZD by ubiquitination; . Reactome R-HSA-5205685; Pink/Parkin Mediated Mitophagy; . Reactome R-HSA-532668; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; . Reactome R-HSA-5357905; Regulation of TNFR1 signaling; . Reactome R-HSA-5357956; TNFR1-induced NFkappaB signaling pathway; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5654726; Negative regulation of FGFR1 signaling; . Reactome R-HSA-5654727; Negative regulation of FGFR2 signaling; . Reactome R-HSA-5654732; Negative regulation of FGFR3 signaling; . Reactome R-HSA-5654733; Negative regulation of FGFR4 signaling; . Reactome R-HSA-5655862; Translesion synthesis by POLK; . Reactome R-HSA-5656121; Translesion synthesis by POLI; . Reactome R-HSA-5656169; Termination of translesion DNA synthesis; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5675221; Negative regulation of MAPK pathway; . Reactome R-HSA-5675482; Regulation of necroptotic cell death; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5684264; MAP3K8 (TPL2)-dependent MAPK1/3 activation; . Reactome R-HSA-5685942; HDR through Homologous Recombination (HRR); . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689877; Josephin domain DUBs; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-5689896; Ovarian tumor domain proteases; . Reactome R-HSA-5689901; Metalloprotease DUBs; . Reactome R-HSA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; . Reactome R-HSA-5693607; Processing of DNA double-strand break ends; . Reactome R-HSA-5696394; DNA Damage Recognition in GG-NER; . Reactome R-HSA-5696395; Formation of Incision Complex in GG-NER; . Reactome R-HSA-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER; . Reactome R-HSA-5696400; Dual Incision in GG-NER; . Reactome R-HSA-6781823; Formation of TC-NER Pre-Incision Complex; . Reactome R-HSA-6781827; Transcription-Coupled Nucleotide Excision Repair (TC-NER); . Reactome R-HSA-6782135; Dual incision in TC-NER; . Reactome R-HSA-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER; . Reactome R-HSA-6783310; Fanconi Anemia Pathway; . Reactome R-HSA-6804756; Regulation of TP53 Activity through Phosphorylation; . Reactome R-HSA-6804757; Regulation of TP53 Degradation; . Reactome R-HSA-6804760; Regulation of TP53 Activity through Methylation; . Reactome R-HSA-6807004; Negative regulation of MET activity; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69231; Cyclin D associated events in G1; . Reactome R-HSA-69298; Association of licensing factors with the pre-replicative complex; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69541; Stabilization of p53; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8849469; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . Reactome R-HSA-8863795; Downregulation of ERBB2 signaling; . Reactome R-HSA-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; . Reactome R-HSA-8866654; E3 ubiquitin ligases ubiquitinate target proteins; . Reactome R-HSA-8875360; InlB-mediated entry of Listeria monocytogenes into host cell; . Reactome R-HSA-8876493; InlA-mediated entry of Listeria monocytogenes into host cells; . Reactome R-HSA-901032; ER Quality Control Compartment (ERQC); . Reactome R-HSA-912631; Regulation of signaling by CBL; . Reactome R-HSA-917729; Endosomal Sorting Complex Required For Transport (ESCRT); . Reactome R-HSA-936440; Negative regulators of RIG-I/MDA5 signaling; . Reactome R-HSA-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; . Reactome R-HSA-937039; IRAK1 recruits IKK complex; . Reactome R-HSA-937041; IKK complex recruitment mediated by RIP1; . Reactome R-HSA-937042; IRAK2 mediated activation of TAK1 complex; . Reactome R-HSA-937072; TRAF6 mediated induction of TAK1 complex; . Reactome R-HSA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; . Reactome R-HSA-975144; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; . Reactome R-HSA-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; . Reactome R-HSA-977225; Amyloid fiber formation; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . SIGNOR P0CG48; -; . ChiTaRS UBC; human; . EvolutionaryTrace P0CG48; -; . GeneWiki Ubiquitin_C; -; . GenomeRNAi 7316; -; . PRO PR:P0CG48; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000150991; -; . ExpressionAtlas P0CG48; baseline and differential; . Genevisible P0CG48; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0030666; C:endocytic vesicle membrane; TAS:Reactome; . GO GO:0044322; C:endoplasmic reticulum quality control compartment; IEA:GOC; . GO GO:0010008; C:endosome membrane; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005741; C:mitochondrial outer membrane; TAS:Reactome; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0002020; F:protease binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0000187; P:activation of MAPK activity; TAS:Reactome; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0044267; P:cellular protein metabolic process; TAS:Reactome; . GO GO:0042769; P:DNA damage response; detection of DNA damage; TAS:Reactome GO GO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome GO GO:1904380; P:endoplasmic reticulum mannose trimming; TAS:Reactome; . GO GO:0016197; P:endosomal transport; TAS:Reactome; . GO GO:0035635; P:entry of bacterium into host cell; TAS:Reactome; . GO GO:0038128; P:ERBB2 signaling pathway; TAS:Reactome; . GO GO:0070987; P:error-free translesion synthesis; TAS:Reactome; . GO GO:0042276; P:error-prone translesion synthesis; TAS:Reactome; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0070911; P:global genome nucleotide-excision repair; TAS:Reactome; . GO GO:0005978; P:glycogen biosynthetic process; TAS:Reactome; . GO GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; TAS:Reactome; . GO GO:0045087; P:innate immune response; TAS:Reactome; . GO GO:0036297; P:interstrand cross-link repair; TAS:Reactome; . GO GO:0075733; P:intracellular transport of virus; TAS:Reactome; . GO GO:0034220; P:ion transmembrane transport; TAS:Reactome; . GO GO:0007254; P:JNK cascade; TAS:Reactome; . GO GO:0016236; P:macroautophagy; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome; . GO GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; TAS:Reactome; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:Reactome; . GO GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; TAS:Reactome; . GO GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0007219; P:Notch signaling pathway; TAS:Reactome; . GO GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome; . GO GO:0000715; P:nucleotide-excision repair; DNA damage recognition; TAS:Reactome GO GO:0000717; P:nucleotide-excision repair; DNA duplex unwinding; TAS:Reactome GO GO:0006297; P:nucleotide-excision repair; DNA gap filling; TAS:Reactome GO GO:0033683; P:nucleotide-excision repair; DNA incision; TAS:Reactome GO GO:0006296; P:nucleotide-excision repair; DNA incision; 5'-to lesion TAS:Reactome . GO GO:0006294; P:nucleotide-excision repair; preincision complex assembly; TAS:Reactome GO GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; TAS:Reactome; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:Reactome; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0006457; P:protein folding; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0016567; P:protein ubiquitination; TAS:Reactome; . GO GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0060544; P:regulation of necroptotic process; TAS:Reactome; . GO GO:1901796; P:regulation of signal transduction by p53 class mediator; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0032479; P:regulation of type I interferon production; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome; . GO GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome; . GO GO:0019985; P:translesion synthesis; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0019058; P:viral life cycle; TAS:Reactome; . GO GO:0019068; P:virion assembly; TAS:Reactome; . GO GO:0016055; P:Wnt signaling pathway; TAS:Reactome; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome InterPro IPR019956; Ubiquitin; . InterPro IPR029071; Ubiquitin-rel_dom; . InterPro IPR019954; Ubiquitin_CS; . InterPro IPR000626; Ubiquitin_dom; . Pfam PF00240; ubiquitin; 9; . PRINTS PR00348; UBIQUITIN; . SMART SM00213; UBQ; 9; . SUPFAM SSF54236; SSF54236; 9; . PROSITE PS00299; UBIQUITIN_1; 9; . PROSITE PS50053; UBIQUITIN_2; 9; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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